Targeted Interventions (TI) for high risk behaviour groups such as Sex Workers, Men having sex with men, Injecting Drug users, and other vulnerable populations like   Migrants and Truck drivers.

Sexually Transmitted Diseases (STD) Control Programme for counseling, and treatment of sexually transmitted infections.  Condom promotion programme to increase the correct and consistent usage of condoms among the population by ensuring its availability and affordability in Kerala.

Information, Education and Communication (IEC) programme is intended to create awareness through prevention messages, a non stigmatizing environment, promote demand generation of services and increase service uptake,  mainstreaming activities through various modes of campaigns and training and increase voluntary blood donation.

Integrated Counseling and Testing Centres (ICTC) cater to all types of clients under one roof and provide cross referrals and linkages to treatment and care services. In more than 100 centres spread across the state, anyone exposed to the risk of HIV infection can get counseled and tested in a confidential and supportive environment. In addition they also attend to cater to clients referred by their medical providers for HIV testing. Pregnant women are tested and counseled at these centers, under Prevention of Parent to Child Transmission (PPTCT) programme.  The PPTCT programme provides treatment of HIV positive expecting mothers. Through a series of measures including provision of antiretroviral drugs to the mother and child, transmission of the infection to their children are greatly reduced.  ICTCs also provide referral for people with prolonged cough for sputum testing for TB and all people who have HIV infection are also referred for sputum testing to identify tuberculosis which is very common in these individuals.

Blood Safety: Provision of adequate quantities of safe blood, when and where needed, is an important strategy for reducing transfusion associated HIV infection The Blood Safety Program ensures safety of blood donations, transfused blood and blood components by improving quality control practices in blood banks and providing blood safety training to personnel.  KSACS oversees and inspects blood banks assuring safety standards. It also aims promotion of voluntary blood donation to ensure adequate quantity of blood is available in the state for those who are in need.

Civil Society Mainstreaming: Mainstreaming HIV/AIDS caters to the need of a multi sectoral response to combat the HIV epidemic. Mainstreaming aims to bring the issues of HIV/AIDS to the mainstream of the society by incorporating them into activities of other governmental departments and private sector companies. This approach follows the current and projected trend of HIV moving out of high risk groups to the general population in the country.

Developing public-private partnerships for HIV prevention and control The program aims to forge partnership with private and public sectors in health service delivery area, as the majority of the population in Kerala depends on the private sector for their health care needs. Thus the private and voluntary sectors can complement prevention efforts taken by KSACS and government agencies in the field of STDs and HIV/AIDS prevention, care, support and treatment.

Care and Support for people living with HIV/ AIDS is provided through Anti retroviral Therapy Centres (ART), Drop in Centres (DIC) and Community Care Centres (CCC). ART centres provide care and free drug treatment (Anti Retro Viral therapy) to HIV positive individuals.   Counseling, nutrition support to women and children living with HIV, and social support   to manage the everyday lives of people living with HIV/AIDS are also part of the package of services.

Programme management and institutional strengthening activities for responding to the AIDS challenge promote the goal of building decentralized systems and processes to facilitate transferring the ownership of health systems to the people and organizations at the local level. This follows the guidelines of NACP III planning and designing implementation of programme is done at the district level.

Capacity building Programmes ensures performance and sector specific growth of the institutional and individual associates of KSACS by providing them with necessary training and tools to better utilize the resources.

Surveillance of HIV/ AIDS is the ongoing systematic collection and analysis of data and the provision of information that leads to action being taken to prevent and control HIV/AIDS. Information is gathered through HIV sentinel surveillance, behavioural surveillance, STD surveillance and ICTCs.

Strategic Information Management system addresses issues of evidence based planning, tracking of the HIV epidemic in the state, assessing performance of various interventions and strategic planning, identifying the pockets of infection and estimating the burden of infection. It aims to create a comprehensive and integrated data warehouse system ascertaining credible, timely, accurate and quality data which can be utilized for planning of future strategies.